DoubleTwist is a universal media hub that is now available as a public beta for Mac OS X. DoubleTwist is like iTunes except it works with not just iPhones and iPods but also with other portable media players.
Not only will DoubleTwist transfer the media to your player for you but it is also capable of converting nearly any video format to the correct format for your device.
The only thing I would suggest to the developers of DoubleTwist is that I don’t want to have to drag and drop media to my device, I would rather set a list of parameters based on ratings, how recent it was last played, etc. and have DoubleTwist transfer it for me. Essentially I want a true iTunes alternative.